kesan makan statin (ubat menurunkan kolesterol)

DIYAnIFA

Did you know that taking Cholesterol-lowering or Statin drugs will cause your CoQ10 levels to plummet!
Do you know that cholesterol-lowering drugs or Statin drugs actually block the natural production of CoQ10 in the body? That's why many users of Statin drugs complain of CoQ10 deficiency symptoms - muscle pain, weakness, tiredness, failing memory, and reduced sexual performance. It's also why many doctors and health experts are now prescribing CoQ10 to those taking cholesterol-lowering medication.


so soklan saya, apa pentingnye coQ10 dlm bdn kita? coQ10 tue ape? my mom makan ubat turunkan paras kolesterol (darah tinggi). so nmpknye regarding to this fact my mum kena makan supplement coQ10. nk tnya all forumers kt sini berkenaan hal nie.

mungkin blh beri ilmu pd forumer yg lain sbb rasanya ramai mak ayah kita makan ubat statin neh.

DIYAnIFA

edit....................

salah tulih.

[ Last edited by  DIYAnIFA at 22-2-2008 07:51 PM ]

zerozone

Coenzyme Q10 ni lebih kurang macam vitamin jugak. Tugasnya menyihatkan sel2 dlm badan.

david01

Ia dikenali sebagai quinone.
Didapati di semua sel badan kecuali kanta mata dan sel darah merah.
Berfungsi Sebenarnya menjana tenaga

Sesetengah penyelidikan mendapati mereka kebolehan mengurangkan kes cancer, sakit jantung, menurunkan tekanan darah...

Oleh kerana tugas utamanya menjana tenaga, jikalau tiada atau kekurangan Q10 ni, jantung (yg memerlukan tenaga yg banyak utk mengepam) akan menghadapi masalah

DIYAnIFA

tu sebabnya kdg2 dengar mak saya bernafas mengah jer. dia duk sebelah keta masa memandu dengar nafas turun naik. risau juga sbb dulu tak macam nie. masa tidur tue memang dh berdengkur.

mungkin kesan ubat statin tue yg menurunkan paras Q10 dlm bdn mak menyebabkan mak cepat letih. sian mak. mak, saya sayang mak....

skang mak bergantung ubat darah tinggi labetalol + norvasc, ubat turunkan kolesterol statin. ingat nak mak makan supplement coQten ngn minyak ikan tue. ok ker tuh? blh ke campur makan ubat sepital ngn supplement?

zerozone

Ada beberapa study menunjukkan supplement CoQ10 ni tak berkesan untuk merawat kekurang CoQ10 yg disebabkan oleh statin. Cara yg terbaik dengan memberhentikan pengambilan statin.

Arissa_Sofea

dah nama pun HMG-CoA reductase inhibitor...anyway, statin ni kn dh proven reduce morbidity and mortality of cardiovascular disease....mkn jer la kalau tknk kna heart attack ke stroke ker

[ Last edited by  Arissa_Sofea at 23-2-2008 07:11 PM ]

DIYAnIFA

mcm tu la plak? nape yer? mgkn ke molekul dia susah nk diserap ke dlm darah.

ade tk paper study tu blh diyan baca..

DIYAnIFA

Originally posted by zerozone at 23-2-2008 03:14 PM
Ada beberapa study menunjukkan supplement CoQ10 ni tak berkesan untuk merawat kekurang CoQ10 yg disebabkan oleh statin. Cara yg terbaik dengan memberhentikan pengambilan statin.

kl gitu tk yah la kot mkn supplement nie. kl mkn minyak ikan tu bagus ker.. sungguh ker bagus ke ade study gak kata tak berkesan? dr zero plz..

tampayaki

Zero,

Tadi I baru ambil result darah, my kolesterol quite high 8++, Doc advise me to take Lovastatin. Jadi apakah harus I ambil ubat tu?

Ada cara lain tak nak turunkan kolesterol secara semula jadi

elsiealaia

I baru dapat result medical check-up. Very high cholesterol too. Tapi doktor tak nak prescribed statin lagi. Doktor suruh I exercise and berdiet dulu. After 6 months kalau cholesterol tak turun baru prescribed ubat.

Nie yang nak pegi jumpa dietician and start exercise dulu. I tak lah kuat makan sangat tapi rumah kita orang mesti ada susu full cream milk and butter hari2. kalau tak de mesti tak leh hidup. tu yang doktor cakap cholesterol tinggi. HDL rendah and LDL tinggi and total cholesterol terus tinggi.

I am very sure that you cuba exercise dulu and also berdiet. Reduce makanan yang ada lemak such as masak lemak....telur and meat. nie yang doktor i suruh lah. makan banyak sayur and buah2.

Let start together....

zerozone

Some research suggests that statin drugs, or HMG-CoA reductase inhibitors, a class of drugs used to lower cholesterol, may interfere with the body's production of CoQ10. However, research on the use of CoQ10 supplements in people taking statins is still inconclusive, and it is not routinely recommended in combination with statin therapy.

A Columbia University study in New York found that 30 days of statin therapy (80 mg/day) decreased Co q10 levels by half.

    * Another study by researchers at Kanazawa University in Japan found that smaller doses of statin drugs can reduce Co q10. After 8 weeks of 10 mg a day statin therapy, Co q10 levels decreased by 40 percent.

Some researchers suggest that this side effect may counteract any benefits of taking statins.

In an article published in the journal Biofactors, cardiologist and researcher Dr. Peter Langsjoen says, "The depletion of the essential nutrient Co q10 by the increasingly popular cholesterol lowering drugs, HMG CoA reductase inhibitors (statins), has grown from a level of concern to one of alarm."

"With ever higher statin potencies and dosages and with a steadily shrinking target LDL cholesterol, the prevalence and severity of Co q10 deficiency is increasingly noticeable."

However, research on whether Co q10 supplements are beneficial in people taking statins is still inconclusive. Co q10 is not routinely recommended in combination with statin therapy.

People particularly vulnerable to statin induced Co q10 deficiency are:

    * over 50 years of age
    * have a history of diabetes
    * have or are at risk for heart failure or cardiomyopathy

zerozone

Originally posted by DIYAnIFA at 23-2-2008 11:47 PM
mcm tu la plak? nape yer? mgkn ke molekul dia susah nk diserap ke dlm darah.

ade tk paper study tu blh diyan baca..

CoQ10 memerlukan lemak (LDL) sebagai bahan pengangkut (binding agent) dalam darah. Bagi orang yg mengambil statin, kadar LDL sangat rendah. Ini menyebabkan CoQ10 beraksi sebagai molukul bebas dan dimusnahkan oleh liver.

zerozone

Saya pernah check sorang pelanggan yg vegetarian....kadar cholestrolnya sangat rendah...sekitar 2.8 je

datintipah

pernah cuba nak jadi vegetarian, makan sayur je tapi dpt bertahan seminggu je...huhuhu....i pun high cholesterol gak, 2 thn lepas reading nyer 10,, lepas tuh doc suruh makan ubat lovastatin tu lah until now.  now reading dah turun ke 5, alhamdullillah.  tp stil doctor tak kasik putus ubat lagi, dia suruh ambik gak....

zerozone

Side effects from long term use of statin.....

Muscle weakness is one of the most documented side effects from long term use of statin medications, with about 1 in 1000 patients experiencing the condition, known as myositis. This could lead to total muscle cell breakdown, called rhabdomyolysis, which could cause kidney failure and in some cases, death.

In addition to muscle weakness from using statins, side effects from long term use of statin drugs may include severe liver problems due to the medication's effect on liver enzymes. Therefore, anyone with liver disease or prior liver issues probably should not take Lipitor, Zetia, Zocor and other cholesterol drugs... all of the manufacturers actually warn against it.

Although muscle weakness from statins and liver problems are of the most concern, much research has shown that they can also cause sexual dysfunction and performance problems, as well as memory loss, personality changes and irritability.

Other side effects from long term use of statin drugs:

1) While cholesterol lowering drugs do lower LDL (bad) cholesterol, they have limited effect on HDL (good) cholesterol, and no effect on triglycerides (fats), an equally important heart disease risk indicator.

2) Statins decrease your body's supply of CoEnzyme Q10 (CoQ10), an essential nutrient for cardivascular strength and function.

3) There are natural cholesterol lowering ingredients, some of which have been shown to outperform statins in lowering cholesterol, without the possible muscle weakness from using statins.

elsiealaia

I need some advice on which drug is best to treat high cholesterol. Statin, Zetia, Niacin and vytorin. You rasa which one is more effective....is it by taking statin or zetia alone or combination of both called Vytorin.

one other question is ..kalau kita ambik statin for certain period of time and cholesterol kita turun..can we stop taking it?. siapa2 ada experience sila bagi komen. Thanks

zerozone

control makan, ambik supplement spt vit E, omega 3,oats, exercise lebih elok untuk turunkan kolestrol. Kalau level cholestrol dah normal  elok berhentikan ubat cholestrol kerana paras cholestrol yg terlalu rendah juga tak elok utk badan. Begitu orang yg mengidap darah tinggi, kencing manis... kalau dah normal elok berhentikan ubat atau kurangkan dose.

elsiealaia

I memang tak makan banyak sangat....jarang sangat makan. makan sikit dah naik badan. Berat maintain below 61kg. Sekarang tengah ambik multivitamin, fish oil and garlic oil. Other than that tak de. My family history ada Diabetes, heart problem and high blood pressure. My dad ada heart prob..tapi kena dalam umur 60. My mun pulak ada heart pro, diabetes and high blood prob tapi agak lewat jugak kena dalam umur 65.

I punya record tak de apa2 masalah kecuali high cholesterol. Ecg ok..blood pressure normal, paras sugar also normal.

My mom punya cholesterol dah turun tapi doktor pakar kat Hospital Besar Sarawak tak kasi stop makan ubat statin...kenapa agak nya tu?. Adakah faktor umur dijadikan asas utama untuk meneruskan atau menghentikan pengambilan ubat statin. Apakah  yang akan berlaku sekiranya ubat Statin dihentikan? Thanks

zerozone

Journal of the American Geriatrics Society

Volume 54 Issue 3 Page 421-430, March 2006

Hydroxymethylglutaryl-CoA Reductase Inhibitors in Older Persons with Acute Myocardial Infarction: Evidence for an Age朣tatin Interaction

OBJECTIVES: To characterize the relationship between hydroxymethylglutaryl-CoA reductase inhibitors (statins) and outcomes in older persons with acute myocardial infarction (AMI).

CONCLUSION: Statin therapy is associated with lower mortality in older patients with AMI younger than 80 but not in those aged 80 and older, as a group. This finding questions whether statin efficacy data in younger patients can be broadly applied to the very old and indicates the need for further study of this group.

Study diatas menunjukkan pengambilan statin dapat mengurangkan risiko sakit jantung pada pesakit berumur 60 tahun tapi kurang 80 tahun. Perlu diingat bahawa cholestrol juga pentng kepada tubuh kita. Statin menurunkan LDL (bad cholestrol). Tapi jika HDL (good cholestrol) terlalu tinggi juga boleh mendatangkan kesan spt LDL.