So you thought you knew about Parkinson, eh?

mbhcsf

Assalamualaikum,

Dear All,


So, we thought we knew basically pretty much about everything on this so called condition - Parkinson Disease, right?
well....i think it is about time we could say...err well not pretty much really...

Meh...semua baca artikel kat bawah from the New York Times...interesting
sebab....

a) kita tahu yg org yg mempunya keadaan ini akan sampai satu tahap yg paling teruk depa tak leh bergerak "froze movement"
b) kita tahu depa ada sedikit kelainan   akibat kecelaruan pergerakan tersebut yang dapat dilihat dengan jelas ketika mereka berjalan - their gait is known to be of shuffling, festinant gait, plus  lacking of arm swings...and of course it affects their mobility at the end.


c) bila baca artikel ini anda dapat melihat ......well bacalah...

d) Saya suka thsi prof...sebab yes, you thought you knew tapi kena ada inquisitive nature and open your mind to certain thing and  well yesss experimenting , validating the evidence later ...

e)  ARtikel ini BARU KAJIAN...bukan satu PENEMUAN yg SAHIH sebab?

kita tidak mempunyai jawapan....


so baca ya...
then tell me what you guys think....

mbhcsf

NEW YORK TIMES

Cycling Provides a Break for Some With Parkinson’s
By GINA KOLATA
Published: March 31, 2010

Dr. Bastiaan R. Bloem of the Radboud University Nijmegen Medical Center in the Netherlands thought he had seen it all in his years of caring for patients with Parkinson’s disease. But the 58-year-old man who came to see him recently was a total surprise.

The man had had Parkinson’s disease for 10 years, and it had progressed until he was severely affected. Parkinson’s, a neurological disorder in which some of the brain cells that control movement die, had made him unable to walk. He trembled and could walk only a few steps before falling. He froze in place, his feet feeling as if they were bolted to the floor.

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cont.
But the man told Dr. Bloem something amazing: he said he was a regular exerciser — a cyclist, in fact — something that should not be possible for patients at his stage of the disease, Dr. Bloem thought.

“He said, ‘Just yesterday I rode my bicycle for 10 kilometers’ — six miles,” Dr. Bloem said. “He said he rides his bicycle for miles and miles every day.”

“I said, ‘This cannot be,’ ” Dr. Bloem, a professor of neurology and medical director of the hospital’s Parkinson’s Center, recalled in a telephone interview. “This man has end-stage Parkinson’s disease. He is unable to walk.”

But the man was eager to demonstrate, so Dr. Bloem took him outside where a nurse’s bike was parked.

“We helped him mount the bike, gave him a little push, and he was gone,” Dr. Bloem said. He rode, even making a U-turn, and was in perfect control, all his Parkinson’s symptoms gone.

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cont.


Yet the moment the man got off the bike, his symptoms returned. He froze immediately, unable to take a step.

Dr. Bloem made a video and photos of the man trying to walk and then riding his bike. The photos appear in the April 1 issue of The New England Journal of Medicine.

After seeing that man, Dr. Bloem asked 20 other severely affected patients about riding a bike. It turned out that all could do it, though it is not clear why.

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Dr. Bloem and other Parkinson’s specialists were amazed. People with Parkinson’s disease can often dance, run, walk smoothly and do complex movements for a few minutes if they are given appropriate signals — emotional or visual cues. There are famous examples, such as a group of Parkinson’s patients who were caught in a fire and managed to run down steps and escape, only to freeze in place when they got outside.

But this effect, known as the kinesia paradox, does not last long. Riding for miles and miles is very different from walking for a few minutes. And until now, Dr. Bloem said, it was not known that patients with Parkinson’s could ride bikes.

“The observation is so novel and exciting that I keep amazing audiences when I show this video during my lectures, even when the audience consists of movement disorder experts,” Dr. Bloem said.

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cont.
Of course, he added, he is not advocating that Parkinson’s patients hop on bikes and go out on busy roads. They need help in mounting a bike and can get into trouble if they have to stop at traffic lights. They need to ride in safe areas. He recommends that patients ride tricycles, or use stationary bikes or trainers — devices that turn road bikes into stationary ones.

Still, he said, bicycling offers patients an opportunity to be symptom-free while they are riding, to look and feel normal, and to get some real cardiovascular exercise even when their disease is so far advanced that they cannot walk.

Parkinson’s experts were intrigued.

“This is an impressive thing,” said Dr. C. Warren Olanow of the Mount Sinai School of Medicine. “He has described a terrifically interesting case, and there are things to learn from it.”

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cont.

Dr. Bloem said one explanation for the finding might be that bicycling uses a different part of the brain than walking and might not be so severely affected by Parkinson’s disease. Or it might be that the rhythmic pressure of the pedals on patients’ feet cues the nervous system to allow a cycling movement.

Bicycling does not cure patients, of course. And, added Dr. Lisa M. Shulman, a neurology professor at the University of Maryland School of Medicine, whether most patients with severe Parkinson’s disease will be able to ride a bike “is an empirical question that would need to be tested.” And, she said, those who cannot do one sort of exercise may be able to do another.

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cont.

But Dr. Bloem said he hoped that perhaps regular exercise might slow the progress of Parkinson’s disease. It does in rats, he said, and he is running a clinical trial in 600 patients to see if exercise also slows the disease in humans.

In the meantime, Dr. Bloem said he knew there was a long way to go from observation to scientific fact. But, he said, that does not mean an observation is useless.

“I’m a strong believer that single cases can provide crucial evidence,” Dr. Bloem said. “Even though this is a single patient, it is very, very provocative.”

Taken from this link :
http://www.nytimes.com/2010/04/01/health/01parkinsons.html .. Date : 3/4/2010. 1: 38 pm
A version of this article appeared in print on April 1, 2010, on page A13 of the New York edition.

mbhcsf

so, nak cuba 600 individuals with parkinson tengok evidence ..keh keh keh

dauswq

so, nak cuba 600 individuals with parkinson tengok evidence ..keh keh keh
mbhcsf Post at 3-4-2010 13:39

interesting fact


i'm curious
whether Parkinson has something to do with lack of specific neurotransmitter


atau disebabkn certain area brain are not functioning  
bcoz saya ada dengar doctor boleh operate otak
untuk kurangkn gegaran caused by Parkison

mbhcsf

interesting fact


i'm curious
whether Parkinson has something to do with lack of specific neurotransmitter


atau disebabkn certain area brain are not functioning  
bcoz saya ada deng ...
dauswq Post at 3-4-2010 14:19

yup...
parkinson's Disease is due to the lack of dopamine - a neurotransmitter , released by subtantia nigra .
so , substantia nigra in the brain has somehow, undergoes some pathological changes - called degeneratives changes which has caused it to produce less and lesser  amount of dopamine.

so dopamine ni penting sebab bhn ni bertanggungjawab sebagai pembawa utusan saraf ke sistem motor / otot yg berpusat di otak terlebih dahulu. bila dopamine ni ada, adalah satu bhgn otak kita yg kawal pergerakan tu akan "inhibit" pergerakan yang "tidak perlu"  dan mengaktifkan serta mengawal / regulate , secara tak langsung ( logically) pergerakan motor yg "perlu".

so segala litar motor / regulatory motor mechanism ni  terletak kat basal ganglia  otak kita. basal ganglia ni akan hantar balik isyarat kat motor cortex otak la , brainstem la, thalamus, subthalamus  tu semua yang sebenarnya pusat motor di otak.

So bila, dopamine reduce you boleh bayangkan yang segala mekanisme kat atas tak berjalan dengan elok. Dan
sebab tu people with parkinson you would see, the slowness in movement, tangan ketaq ketaq dalam keadaan rehat etc etc..


yang pasal treatment tu well - yg ada sekarang ubat jer lah
yg lelain tu deep brain stimulation laaa, yg letak stem cells semua tu MASIH dalam peringkat KAJIAN....

chewan

dan cm mana pulak ada kajian yg mnyatakan penggunaan laser pd machine fotostat ada implikasi pada pengguna terutamanya risiko penyakit parkinson

mbhcsf

yang satu lagi ineterestingnya ialah pesakit parkinson ni kalau bagi depa jalan depa you know would not eb able to walk steadily ....or in a straight line

TAPI
bila kita bagi depa jalan dan kita drwa satu line liurus kan lantai okay jer depa jalan

so kat sinilah yg
tertimbulnya satu persoalan : adakah VISUAL cue or any cue boleh membantu  depa ni bergerak lancar , if so

apakah mechanism

mizsela

based on what i learn schizophrenia  nie masalah dopamine....(one of the factors lah)

eh ape aku ngarut pasal scizo nie

mizsela

tersilap thread..nanti nk bincang pasal scizo lah

mbhcsf

schizo ? fine....yes  la ni depa dok focus frontal lobe or  the lobe of the brain yg activate by dopminergic receptors tu sebba ada pengaktifan kat situ
yup...are you  in psychiatry?
sebab depa dok focus tang  situ ialah

a) auditory hallucination tu depa dapati berlaku sama dgn pengaktifan ? frontal lobe of teh brain
b) ada kaitan mekanisme ini dengan dopamine receptor kalau tak salah ...

mbhcsf

dan cm mana pulak ada kajian yg mnyatakan penggunaan laser pd machine fotostat ada implikasi pada pengguna terutamanya risiko penyakit parkinson
chewan Post at 3-4-2010 16:04

associative studies kan?
well ada jugak yg kata aluminium based subtances pun kena jugak

i tak tahu to be honest ....how's the proposed  mechanisme yer ?
you nak elaborate  sikit ker ?

mizsela

schizo ? fine....yes  la ni depa dok focus frontal lobe or  the lobe of the brain yg activate by dopminergic receptors tu sebba ada pengaktifan kat situ
yup...are you  in psychiatry?
sebab depa dok ...
mbhcsf Post at 3-4-2010 16:54

suku sakat psychology jer.....masih study...saje je...saje bincang2..bleh mantapkan pengetahuan

mbhcsf

18# mizsela

yup...it is okay
so far what you have already knew about Schizo then?

mbhcsf

which bit pf spychology did u learn then...interesting ...